Tirzepatide and GLP-1: What’s the Difference?

July 3, 2025

Tirzepatide and GLP-1: What’s the Difference?

July 3, 2025

Breakthrough Medications for Weight Management

Medications that support weight management and blood sugar control have seen major breakthroughs in recent years. Among the most promising are GLP-1 receptor agonists such as semaglutide and liraglutide, and a newer, dual-action medication called tirzepatide.


While they are sometimes spoken about interchangeably, these treatments are not identical. Understanding the distinctions between them can help patients make more informed choices, especially when guided by a knowledgeable provider.


At ATX Infusion and Wellness, we offer evidence-based therapies designed to align with each patient’s goals. This article will outline the fundamental differences between tirzepatide and GLP-1 medications—including how they work, what to expect, and what to consider.

Understanding GLP-1: How It Works

GLP-1, or glucagon-like peptide-1, is a hormone the body naturally produces in response to food. It plays a key role in regulating:

  • Insulin secretion
  • Blood sugar levels
  • Appetite and satiety


GLP-1 receptor agonists are synthetic versions of this hormone designed to extend its activity in the body. They help patients feel fuller sooner, delay gastric emptying, and reduce blood sugar spikes after meals. These effects support both type 2 diabetes management and weight loss in eligible patients.


Some common GLP-1 medications include:

  • Semaglutide (brand names include Ozempic, Wegovy)
  • Liraglutide (brand names include Saxenda, Victoza)


In clinical trials, these medications have shown an average weight reduction of around 10-15% of body weight, depending on the dose and duration.

What Is Tirzepatide?

Tirzepatide is a more recent innovation in this class of therapies. While it includes GLP-1 activity, what sets it apart is its dual mechanism:


It targets both the GLP-1 receptor and the GIP receptor.


GIP, or glucose-dependent insulinotropic polypeptide, is another gut hormone that:

  • Stimulates insulin release
  • Supports fat metabolism
  • May contribute to enhanced weight loss when paired with GLP-1


By acting on both pathways, tirzepatide delivers a synergistic effect that may produce greater results than GLP-1 alone. The first FDA-approved tirzepatide medication is Mounjaro, originally indicated for type 2 diabetes. Weight-loss-specific approval for tirzepatide-based medications has since followed for certain patient populations.

Expected Results: What the Research Shows

According to multiple clinical studies, tirzepatide has demonstrated superior weight loss outcomes compared to GLP-1-only medications. For example:

  • In the SURMOUNT-1 trial, participants taking tirzepatide lost up to 22.5% of body weight over 72 weeks.
  • In head-to-head comparisons, tirzepatide outperformed semaglutide in both blood glucose control and weight reduction for type 2 diabetes patients.


These results are promising, but it is important to understand that individual outcomes vary based on starting weight, diet, activity level, and adherence to treatment protocols.

Side Effects and Safety Considerations

Both tirzepatide and GLP-1 medications share similar side effects, most of which are gastrointestinal and typically subside over time. These may include:

  • Nausea
  • Vomiting
  • Diarrhea or constipation
  • Appetite changes
  • Mild fatigue


Patients with a history of pancreatitis, certain thyroid conditions, or gastrointestinal disorders should consult with a qualified provider before starting therapy. Neither tirzepatide nor GLP-1 medications are recommended during pregnancy or breastfeeding.


At ATX Infusion and Wellness, all patients are carefully screened to determine eligibility and monitored throughout treatment to help manage side effects and optimize results.

Which One Is Right for You?

There is no one-size-fits-all solution. Both tirzepatide and GLP-1 therapies have demonstrated strong benefits for:

  • Weight management
  • Blood sugar control
  • Metabolic improvement


Tirzepatide may offer enhanced results for some individuals due to its dual hormone targeting, but the choice depends on medical history, goals, and tolerability.

Learn More with a Personalized Consultation

If you are exploring advanced weight management strategies, ATX Infusion and Wellness offers a range of options including tirzepatide and GLP-1 therapies, as well as supporting peptides to help preserve muscle mass and metabolic function during treatment.


To learn which option aligns with your goals, contact us today to schedule a consultation. All recommendations are based on current research and tailored to your health profile—because sustainable results begin with the right guidance.

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